A Role of the Endothelial Cell Protein C Receptor(EPCR) for Protein C Activation.
نویسندگان
چکیده
منابع مشابه
Endothelial cell protein C receptor plays an important role in protein C activation in vivo.
Endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-thrombomodulin complex about 5-fold in vitro. Augmentation is EPCR concentration dependent even when the EPCR concentration is in excess of the thrombomodulin. EPCR is expressed preferentially on large blood vessel endothelium, raising questions about the importance of protein C-EPCR interaction for augment...
متن کاملThe endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.
Protein C activation on the surface of the endothelium is critical to the negative regulation of blood coagulation. We now demonstrate that monoclonal antibodies that block protein C binding to the endothelial cell protein C receptor (EPCR) reduce protein C activation rates by the thrombin-thrombomodulin complex on endothelium, but that antibodies that bind to EPCR without blocking protein C bi...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Endothelial cell protein C receptor plays an important role in protein C activation in vivo
Endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-thrombomodulin complex about 5-fold in vitro. Augmentation is EPCR concentration dependent even when the EPCR concentration is in excess of the thrombomodulin. EPCR is expressed preferentially on large blood vessel endothelium, raising questions about the importance of protein C-EPCR interaction for augment...
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ANTICOAGULANT PATHWAY P ROTEIN-C is a vitamin-K-dependent plasma zymogen.’ After activation, activated protein-C differs from the vitamin-K-dependent plasma clotting factors in that it potently inhibits coagulation5 by inactivating factors V6’7 and VIII,7’8 and it facilitates fibrinolysis in vivo9”#{176} by elevating circulating plasminogen activator levels.tO Clinical evidence of protein-C inv...
متن کاملEndothelial cell protein C receptor: role beyond endothelium?
Endothelial cell protein C receptor (EPCR) is a type 1 transmembrane glycoprotein with homology to the major histocompatibility complex (MHC)-class 1/CD1 family of molecules.1 EPCR was isolated and cloned as an endothelial cell-specific, high selectivity and high affinity binding protein for protein C (PC) and activated PC (APC).1 EPCR binds PC on the endothelial surface and presents it to the ...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 1999
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.10.469